Dental Plaque at the Gingival Margin

• Characteristics, interaction among organisms and local immune response, consequences over defined periods of time, influencing factors.

Gingival Inflammation

• Gingivae in health and disease: characterisation of extent of inflammation, markers, impact on rest of periodontium and oral health, longitudinal sequalae.

Enamel Health

• Teeth are subject to numerous challenges throughout the day from dietary sugars, acids and bacteria. Despite the use of fluoridated toothpaste and mouthwash, all these factors have contributed to a significant rise in the number of fillings, enamel wear and sensitivity. Therefore, we are seeking solutions that would protect tooth enamel from these challenges and/or repair the damage that has been caused, and/or drive further understanding of the conditions.

Dentine Hypersensitivity

• Dentin hypersensitivity is a relatively common condition; it is one of the most commonly encountered clinical problems in dentistry. Dentine hypersensitivity is characterized by tooth pain in response to stimuli such as hot and cold food and can have a marked impact the enjoyment of daily activities and quality of life. However, the condition is manageable, and we continue to seek to develop products that help prevent the pain of dentine hypersensitivity, and explore new understandings on the condition, including impacts on quality of life, objective measures of pain and physiological parameters.

Toothbrushes

• Epidemiological insights around toothbrushing
• Role of toothbrushes in aetiology of dentine hypersensitivity
• Techniques to clinically measure cervical /gingival abrasion

The Burden of Tooth Loss

• Implications and consequences: Function, Oral Health, Quality of Life
• Role of dental professionals in managing change/transition for patients facing/ living with tooth loss

Care of Appliances as Part of Daily Oral Hygiene Routine

• Oral hygiene needs of partially dentate patients
• Evidence base for prevention of oral diseases in partially dentate populations

Fit and Performance of Removable Dentures

• Masticatory function
• Oral health
• Patients perceived needs

Oral and Systemic Health Linkage

• Bi-directional linkage of oral health and systemic health conditions (e.g., diabetes, rheumatoid arthritis)
• Future technologies/diagnostic tools to assess oral health and systemic health linkage
• Role of the dental professionals in holistic whole-body wellbeing

Oral Microbiome

• Role of oral bacteria (composition and function) in health and disease.

Haleon scientists research and develop self-treatment options to manage a range of mild to moderate pain types. The goal of Haleon's research in pain is to provide treatments and interventions that significantly improve the lives of patients living with a range of painful conditions.

We welcome research proposals especially those that evaluate:

• The use of non-prescription pain relievers in mild to moderate pain conditions
• Use of oral and topically applied natural products for pain
• Combination treatments in the management of pain

• Upper respiratory tract infections
• Allergic and non-allergic rhinitis
• Air pollution

Wellness category is interested in receiving and reviewing proposals related to research in dietary supplements (DS):

• Healthy Ageing
• Immunity and inflammation
• Cardiovascular and metabolic related issues
• Brain health
• Real World Data research methods on DS product outcome and efficacy
• Immunity and nutrition
• Energy-yielding cellular metabolism
• Inflammation and nutrition
• Self-care and food supplement efficacy

Digital health can be broadly defined as the use of digital technology, data and the internet to improve either access, efficiency, the consumer/patient experience, or outcomes (or a combination of these) in healthcare.

Haleon welcomes research proposals in the field of digital health. We have a broad scope of interest for such proposals and are keen to hear of any which may include studies that:

• Assess the use of apps and other digital technologies to improve health outcomes or the patient/consumer experience in any of the therapy areas in which Haleon has a publicly declared interest
• Address the areas of resilience, pain, anxiety, smoking cessation (and other forms of addiction), health-related behaviour change, weight management, wellness, mental health, oral health, allergy, infectious diseases and cold & flu
• Assess the utility of digital therapeutics or platforms in areas of interest, where the therapeutic/platform may be a standalone intervention or an adjunct to a conventional medicine/medical device
• Investigate the potential health benefits of wearable technologies
• Investigate innovative ways to collect real world evidence on healthcare interventions
• Investigate innovative ways to monitor/assess the safety of healthcare interventions
• Investigate consumer, patient, HCP, regulator or policymaker attitudes to, and acceptance of, digital health interventions
• Investigate how digital health interventions may reduce the burden on healthcare systems